Show Notes
This release contains only the music track from Base by Base Episode 115.
Song title: Dub the Ras Down
Original Base by Base episode: 115: Neurofibromin, KRAS, and new targets for NF1 tumors
Article metadata:
Article title: A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system
Journal: PNAS
DOI: 10.1073/pnas.2506823122
Reference: Vasudevan HN, Arang N, Sacconi Nunez M, Kennedy P, Payne E, Mohabeer S, Chien J, Wright A, Sale MJ, Kroganc NJ, Forget A, McCormick F. A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system. Proc Natl Acad Sci U S A. 2025;122(27):e2506823122. doi:10.1073/pnas.2506823122
Lyrics:
Verse 1
In the lab with the bright-screen glow,
Signal rising where it shouldn’t go.
When NF1 slips, the warning’s loud,
Ras runs hot like a thundercloud.
Pre-Chorus
Kinase wheels start to spin too fast,
ERK on fire, the brakes don’t last.
Cells keep time with a hard new pace,
But we’re tracing the switch in the bassline space.
Chorus
Dub the Ras down, turn the red light low,
Cut that current where the wild tides flow.
If the old road bends and the MEK signs fade,
We’ll find a new door in the choices we made.
Dub the Ras down—let it slow, let it breathe.
Verse 2
Maps of messages, RNA streams,
Protein sparks in phospho-dreams.
Close-up signal says “look right here”:
KRAS in the shadows, pulled in near.
Bridge
Some doors shut, some pathways fake,
One block slips, another will wake.
SHP2 pulls broader, holds the line,
While SOS swaps masks in the meantime.
So we aim for the core—steady hands, clear sound,
Keep the rhythm, keep the noise pinned down.
Final Chorus
Dub the Ras down, turn the red light low,
Drop that pressure till the good cells glow.
When resistance talks, we listen, we learn,
But the beat stays brave and the pages still turn.
Dub the Ras down—ERK cools, cycles release,
And the night shifts into a cautious peace.
