One-Base Truth

This release contains only the music track from Base by Base Episode 145.

Song title: One-Base Truth
Original Base by Base episode: 145: hs-MSI Validation: Detecting CMMRD and Pinpointing PMS2

Article metadata:
Article title: A Validated Highly Sensitive Microsatellite Instability Assay Accurately Identifies Individuals Harboring Biallelic Germline PMS2 Pathogenic Variants in Constitutional Mismatch Repair Deficiency
Journal: Clinical Chemistry
DOI: 10.1093/clinchem/hvae027
Reference: Marín F, Canet-Hermida J, Bianchi V, et al. A Validated Highly Sensitive Microsatellite Instability Assay Accurately Identifies Individuals Harboring Biallelic Germline PMS2 Pathogenic Variants in Constitutional Mismatch Repair Deficiency. Clinical Chemistry. 2024;70(5):737–746. doi:10.1093/clinchem/hvae027

Lyrics:
Verse 1
White coats, bright screens, midnight on repeat
Counting tiny stutters in the DNA beat
In blood so quiet, in tumors that shout
Looking for the crack where the truth leaks out

Pre-Chorus
A missing repair can slip through the seams
But patterns don’t lie in the data streams
One gene leaves a fingerprint, sharp and clear
Turn the noise to signal, bring it near

Chorus
Run it high-sensitive, light up the dark
Microsatellites spark, spark, spark
When mismatch repair falls out of tune
We read the scars like a rising moon
And if it’s PMS2, the one-base shows
A clean little answer where the doubt used to grow

Verse 2
Panels on the table, one-ninety-two lines
Every repeat a question, every call a sign
Scores that climb higher when the clock starts young
A warning in the rhythm, before words are sung

Bridge
Not every case is loud, not every clue is wide
Sometimes it’s a single step where the truth will hide
So we map the indels, let the numbers talk
Guiding watchful days down a steadier walk

Final Chorus
Run it high-sensitive, light up the dark
Microsatellites spark, spark, spark
From blood to tissue, we can name the tone
So the next move’s chosen, not guessed alone
And if it’s PMS2, the one-base shows
A clean little answer—now the future knows