Show Notes
This release contains only the music track from Base by Base Episode 213.
Song title: BRAIN-MAGNET Atlas
Original Base by Base episode: 213: BRAIN-MAGNET: a functional atlas for non-coding variants
Original episode link: https://basebybase.castos.com/episodes/brain-magnet-ncre-atlas
Article metadata:
Article title: BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants
Journal: Cell
DOI: 10.1016/j.cell.2025.10.029
Reference: Deng R., Perenthaler E., Nikoncuk A., et al., BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants, Cell 189, 1–20 (2026). https://doi.org/10.1016/j.cell.2025.10.029
Lyrics:
[Verse]
BRAIN-MAGNET, a convolutional neural network trained on 148,198 functionally tested non-coding regulatory elements
A functional genomics atlas for interpretation of non-coding variants
A functional genomics atlas of 148,198 regulatory regions in neural stem cells
Comparative-ChIP-STARR-seq identifies primed non-coding regulatory elements
[Chorus]
Predicts enhancer activity directly from DNA sequence and identifies nucleotides essential for function
Prioritize disease-relevant non-coding variants, advancing functional interpretation of the regulatory genome
In neurodevelopment and neurological disease
Fine-mapping of GWAS loci and prioritizing candidate disease-causing rare non-coding variants
[Bridge]
BRAIN-MAGNET predicts NCRE activity from DNA sequence and identifies nucleotides required for NCRE function
Provides gene regulatory insights into neural stem cells and evidence of NCRE priming already in embryonic stem cells for later neural activity
Together, this NCRE atlas and BRAIN-MAGNET represent a powerful resource, possibly aiding the identification of previously unrecognized enhanceropathies
