Show Notes
This release contains only the music track from Base by Base Episode 6.
Song title: Double-Marked, Still Alive
Original Base by Base episode: 6: TRMT1, tRNA m2,2G, and Intellectual Disability
Article metadata:
Article title: Bi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2025.03.015
Reference: Efthymiou S, Leo CP, Deng C, et al. Bi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder. Am J Hum Genet. 2025;112:1117–1138. doi:10.1016/j.ajhg.2025.03.015
Lyrics:
Verse 1
Midnight in the lab, the lights don’t blink
We read the letters faster than we think
Two quiet breaks in a single name
And growing minds don’t grow the same
Pre-Chorus
Tiny scribes on RNA, you’re supposed to leave a sign
A double mark on guanine, keep the timing in line
But the ink runs out, the page turns thin
And the whole song stumbles from within
Chorus
When the m2,2G fades, the rhythm slips away
But we can trace the missing beat and name what went astray
Two hits, one gene, and the proof is in the line
We’ll light the path for every child—one diagnosis at a time
Verse 2
Some cuts the message wrong, splicing out the truth
Some locks the hands that hold the tRNA close to you
Some dulls the spark that makes the chemistry go
And cells slow down where they used to glow
Bridge
In a small bright tank, a little heart learns to swim
But the brain grows quiet at the edges, stark and dim
Still the data sings: it’s not a curse in the air
It’s a mod you can measure, a break you can repair
Final Chorus
When the m2,2G fades, the rhythm slips away
But we can trace the missing beat and name what went astray
Two hits, one gene, and the proof is in the line
We’ll light the path for every child—one diagnosis at a time
