Show Notes
This release contains only the music track from Base by Base Episode 453.
Song title: Turn the Tide in My Brain
Original Base by Base episode: 453: Efavirenz slows sCJD progression by reshaping brain cholesterol
Article metadata:
Article title: Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism
Journal: JCI Insight
DOI: 10.1172/jci.insight.190296
Reference: Ali T, Cashion J, Hannaoui S, Ahmed-Hassan H, Schatzl H, Gilch S. Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism. JCI Insight. 2025;10(14):e190296. https://doi.org/10.1172/jci.insight.190296.
Lyrics:
Verse 1
In the quiet of a failing light,
Something twisted, running wild inside.
Pages blur, but I still can fight,
If there’s a switch that turns the dark aside.
Pre-Chorus
Low dose, late start, still a spark in the storm,
A hidden lever in the chemistry.
If the wheels can spin where they used to deform,
Then maybe time can bend for me.
Chorus
Turn the tide in my brain, let the current run clean,
Break the loop where the shadows remain.
If you move the cholesterol, you can change what’s unseen—
Hold the line, buy the days, ease the strain.
Verse 2
Bright screens, long nights, counting every sign,
Watching markers fall like ash in air.
Less of that resistant, jagged spine,
As the buildup loosens its grip in there.
Bridge
Wake the enzyme up, let it open the gate,
Send the excess out in a safer form.
Cool the signal that keeps feeding the weight,
Drain the droplets, quiet down the swarm.
Final Chorus
Turn the tide in my brain, let the current run clean,
From the first hard miles to the late-stage rain.
If you move the cholesterol, you can change what’s unseen—
Hold the line, steal the hours, break the chain.
