Show Notes
This release contains only the music track from Base by Base Episode 47.
Song title: Hotspot Hearts, Wildcard Ends
Original Base by Base episode: 47: Encoding and decoding chemokine-GPCR selectivity
Article metadata:
Article title: Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network
Journal: Cell
DOI: 10.1016/j.cell.2025.03.046
Reference: Kleist AB, Szpakowska M, Talbot LJ, et al. Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network. Cell. 2025;188:3603–3622. doi:10.1016/j.cell.2025.03.046
Lyrics:
Verse 1
Late-night lab, bright screen glow
Lines connect where the currents go
A tiny knot in the protein storm
Same old spark in a thousand forms
Pre-Chorus
Not every touch is meant to last
Some bonds are built to change that fast
A hidden rule in every bend
A steady core, a wildcard end
Chorus
One small hotspot, it knows your name
Holds the door for every flame
Then the soft motifs decide the route
Tune the signal in or out
From shared hello to chosen friends
Hotspot hearts, wildcard ends
Verse 2
Two big families, different sway
Same first step, then split the way
Loops and tips like subtle keys
Clicking locks with SLiM ease
Bridge
If we can read what the network writes
We can rewrite the midnight fights
Trade the pull, redirect the call
Guide the rush through the hospital halls
A smarter map for where cells run
Turn the dial, not just the gun
Final Chorus
One small hotspot, it knows your name
Holds the door for every flame
Then the soft motifs decide the route
Tune the signal in or out
We can edit what the system sends
Hotspot hearts, wildcard ends
