Show Notes
This release contains only the music track from Base by Base Episode 82.
Song title: Escape From Senescence
Original Base by Base episode: 82: JAK2 inhibition drives RAS clonal selection in myelofibrosis
Article metadata:
Article title: JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms
Journal: Nature Communications
DOI: 10.1038/s41467-025-60884-1
Reference: Maslah N, Kaci N, Roux B, et al. JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms. Nat Commun. 2025;16:6270. doi:10.1038/s41467-025-60884-1
Lyrics:
Verse 1
White coat nights under bright screen glow,
We quiet one signal, watch another grow.
Turn down the JAK, the static fades,
But in the hush, a shadow upgrades.
Pre-Chorus
A fork in the wiring, a hidden spark,
A clone in the corner learns to move in the dark.
What looked like control, a gentler brake,
Can open a door that we didn’t make.
Chorus
When you dim that pathway, the other one runs,
MAPK rising like a second sun.
RAS in the bloodstream, taking the stage,
Escaping the lock of a cell’s old cage.
So read the code before you choose the fight,
And pair the brakes to hold the line.
Verse 2
Fishbone charts in a tide of time,
Alleles climb in a crooked rhyme.
Single cells tell it frame by frame:
Same driver heart, but the cast can change.
Bridge
Screen before the first dose, keep watch as you go,
Track the small letters that start to show.
If the pathway splits, don’t chase one lane—
Two hands on the wheel in a molecular rain.
Final Chorus
When you dim that pathway, the other one runs,
MAPK rising like a second sun.
RAS in the bloodstream, taking the stage,
Escaping the lock of a cell’s old cage.
So read the code before you choose the fight,
And pair the brakes—hold the line, hold the line.
