Show Notes
This release contains only the music track from Base by Base Episode 90.
Song title: Cascade on Fire
Original Base by Base episode: 90: Sex, APOE-ε4 and TREM2: Who drives tau in medial temporal and neocortex?
Article metadata:
Article title: Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions
Journal: Nature Communications
DOI: 10.1038/s41467-025-60370-8
Reference: Giorgio J, Jonson C, Wang Y, Yokoyama JS, Wang J, Jagust WJ, et al. Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions. Nature Communications. 2025;16:5812. doi:10.1038/s41467-025-60370-8
Lyrics:
Verse 1
Under bright screens in the after-hours glow,
We trace the first sparks where the quiet tides flow,
Amyloid rises like a slow-moving sea,
Then tau starts to write what we’re starting to be.
Pre-Chorus
Not every heart beats the same in the scan,
Not every warning arrives with a plan,
A single small letter, a shift in the code,
Turns a doorway of memory into a road.
Chorus
It’s the cascade on fire, watch it climb, watch it run,
From the gate to the skyline where the damage gets done,
If you wait, it gets louder, if you move, you can steer,
Read the signals early—make the pathway clear.
Verse 2
Some carry ε4 like a weight in the light,
And the entorhinal edge burns hotter at night,
Some rare TREM2 turns the spread into speed,
And the neocortex learns what it never should need.
Bridge
So don’t call it fate when the lines intersect,
It’s an interaction—cause and effect,
Stratify the timing, don’t gamble the chance,
Stop the spark at the doorway before it can dance.
Final Chorus
It’s the cascade on fire, but we’re not standing still,
We can meet it with a mirror and a measured will,
Hit amyloid early, and don’t let tau take the wheel,
Turn the map into medicine—make the future real.
