Show Notes
This release contains only the music track from Base by Base Episode 94.
Song title: Same Body, Different Codes
Original Base by Base episode: 94: Intraindividual epigenetic heterogeneity in advanced prostate cancer
Article metadata:
Article title: Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer
Journal: Nature Communications
DOI: 10.1038/s41467-025-60654-z
Reference: Mizuno K., Ku S-Y., Venkadakrishnan VB., et al. Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer. Nature Communications (2025). DOI: https://doi.org/10.1038/s41467-025-60654-z
Lyrics:
Verse 1
One patient, many shadows on the scan
Same name on the chart, different plans
Quiet switches in the methylation light
Lineage stories changing overnight
Pre-Chorus
Marks on the genome, drifting like smoke
A surface flag can vanish as a joke
If we don’t look close, we miss the sign
Right target, wrong time
Chorus
Same body, different codes
Different keys in different roads
Read the silence, read the glow
Find the door before it closes
Same body, different codes
But we learn where the signal goes
Map the marks, then choose the shot
Hit what’s there, not what we thought
Verse 2
Across the spread, some patterns still align
But one site whispers, “I’m not your kind”
AR goes dim, ASCL1 takes the stage
New masks turning with the page
Bridge
Double-negative, split in two
One with BMP4 breaking through
One immune-lit, sharp and wide
We trace the links we can’t deny
And when the pathway starts to shout
We dial it down and test it out
Final Chorus
Same body, different codes
Different storms in different nodes
Read the silence, read the glow
Bring the therapy where it goes
Same body, different codes
Now the map is what we hold
Methyl marks and open chromatin
Say when to strike—so we can win
