Show Notes
This release contains only the music track from Base by Base Episode 60.
Song title: Signal in the Static
Original Base by Base episode: 60: Epi-PRS: Genomic LLMs and imputed epigenomics boost polygenic prediction
Article metadata:
Article title: Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features
Journal: PNAS
DOI: 10.1073/pnas.2419202122
Reference: Zeng W., Guo H., Liu Q., Wong W.H. Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features. PNAS. 2025;122(24):e2419202122. doi:10.1073/pnas.2419202122
Lyrics:
Verse 1
I’ve got a whole genome on a midnight screen,
Letters and numbers where the truth has been.
But what if the meaning isn’t in the code alone?
What if it sings in the way it’s shown?
Pre-Chorus
Turn the dimmer up on the silent parts,
Where the switches hide in the dark.
Not just “what you have” but “what it can do”,
A living context breaking through.
Chorus
We found a signal in the static, clear and bright,
Regulators in the wiring, turning risk into light.
From rare to common, from guess to proof,
We climb the curve when the model tells the truth.
Read the code, feel the spark—
Epigenomic footprints in the dark.
Verse 2
Different tissues, different maps to the same old strain,
One variant whispers, another brings the rain.
Nonlinear footsteps, learning as we grow,
The bigger the crowd, the more it starts to show.
Bridge
So I won’t settle for a score that’s blind,
I want the why in the in-between lines.
A bridge from genotype to what you become,
A chorus of features, beating like a drum.
Final Chorus
Yeah, we found a signal in the static, clear and bright,
Cell-type shapes and shadows, turning risk into light.
From rare to common, from noise to proof,
We climb the curve when the model tells the truth.
Read the code, feel the spark—
Epigenomic footprints in the dark.
