Show Notes
This release contains only the music track from Base by Base Episode 65.
Song title: Where the Pseudoexon Hides
Original Base by Base episode: 65: Hidden splice variants in FBN1 — genome sequencing finds Marfan diagnoses
Article metadata:
Article title: Utility of genome sequencing and group-enrichment to support splice variant interpretation in Marfan syndrome
Journal: Genetics in Medicine
DOI: 10.1016/j.gim.2025.101477
Reference: Walker S, Bunyan DJ, Thomas HB, et al. Utility of genome sequencing and group-enrichment to support splice variant interpretation in Marfan syndrome. Genetics in Medicine (2025). doi: https://doi.org/10.1016/j.gim.2025.101477
Lyrics:
Verse 1
In the quiet code between the lines,
A tiny switch can redesign.
Not in the spotlight, not in the frame,
But it bends the message all the same.
We trace the heartbeat back to a name.
Pre-Chorus
Widen the window, let the pattern show,
From fifty steps to farther roads.
If the signal’s faint, we won’t let go—
We’ll find the cut, we’ll find the sew.
Chorus
Hear it—splice, splice, changing the sound,
A hidden door where none was found.
Deep in the intron, it turns around,
Writes a new verse, knocks the rhythm down.
But when we see it, we can stand our ground.
Verse 2
Screens glow late with a careful guess,
Then RNA tells what the DNA missed.
A band on a gel, an extra trace,
A borrowed piece in the wrong place.
One family’s answer, a steadier pace.
Bridge
Not every clue is easy to hear,
Some transcripts vanish, some lanes aren’t clear.
Still, with each test we pull it near—
Prediction to proof, from doubt to steer.
And watchful hearts get time, not fear.
Final Chorus
Hear it—splice, splice, changing the sound,
A hidden door where none was found.
Deep in the intron, it turns around,
Writes a new verse, knocks the rhythm down.
Now we name it, and we turn it into ground.
