Show Notes
This release contains only the music track from Base by Base Episode 433.
Song title: Lactate Lights the Switch
Original Base by Base episode: 433: Lactate, HSP90α and the Mitochondrial Switch
Article metadata:
Article title: HSP90α lactylation orchestrates PGC1α and LRPGC1 nuclear translocation driving mitochondrial biogenesis
Journal: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.2528979123
Reference: Wu G., Li H., He T., et al. HSP90α lactylation orchestrates PGC1α and LRPGC1 nuclear translocation driving mitochondrial biogenesis. PNAS. 2026;123(30):e2528979123. doi:10.1073/pnas.2528979123
Lyrics:
Verse 1
Late-night numbers on a glowing screen
A quiet signal turns the gears unseen
Lactate in the air like a spark in the room
Telling small engines how to make more room
Pre-Chorus
A chaperone hears the chemical call
Two tiny marks and the dominos fall
Locks and latches, line by line
Open the door to a power-up sign
Chorus
Lactate lights the switch, let the whole cell sing
HSP90 holds the fire like a wedding ring
PGC1 on the move to the nucleus tonight
Building more mitochondria, raising up the light
Verse 2
K58 pulls ULK1 into place
S39 written like a starter’s pace
K616 shuts CDK5 outside
So S596 can’t slow the ride
Bridge
NRF1, NRF2—blueprints in the dark
New membranes rising from a single spark
More fuel, more breath when the morning begins
A brighter charge under the skin
Final Chorus
Lactate lights the switch, let the whole cell sing
HSP90 turns the signal into everything
PGC1 and LRPGC1 cross that open door
More mitochondria waking, asking for more
