Show Notes
This release contains only the music track from Base by Base Episode 460.
Song title: Same Dial
Original Base by Base episode: 460: The lupus variant that also sharpens antiviral defense
Article metadata:
Article title: A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.08.016
Reference: Virolainen, S.J., Creighton, K., Dashtiahangar, M., et al., Waggoner, S.N., Weirauch, M.T., and Kottyan, L.C. (2026). A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity. The American Journal of Human Genetics 113, 1-22. https://doi.org/10.1016/j.ajhg.2026.08.016
Lyrics:
Verse 1
Two letters in a single gene.
Most of the world is carrying them.
Not the rare thing. The common thing.
Mantra
Turn it up.
The virus falls.
Turn it up.
The body turns.
Verse 2
Into the nucleus faster.
Onto the DNA tighter.
More interferon out the other side.
Mantra
Same dial.
Both ways.
Same dial.
Both ways.
Verse 3
In the mouse lung, less virus by morning.
In the same mouse, antibodies against its own DNA.
Nobody got to choose one without the other.
Bridge
Older than the plagues we wrote down.
Already common before the counting started.
It was never waiting to become useful.
It already was.
Mantra
Turn it up.
The virus falls.
Turn it up.
The body turns.
Outro
One point one eight.
A small risk, carried by almost everyone.
Same dial.
Both ways.
Same dial.
