Show Notes
This release contains only the music track from Base by Base Episode 126.
Song title: Miswired in 3D
Original Base by Base episode: 126: Smith-Magenis Syndrome: Chromatin Rewiring to Hyperexcitable Neurons
Article metadata:
Article title: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2025.07.020
Reference: Lee Y.-J., Chang Y.-T., Cho Y., Kowalczyk M., Dragoiescu A., Pacis A., Kailasam S., Lefebvre F., Zhang Q., Gao X., Huang W.-H. (2025). Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models. The American Journal of Human Genetics 112, 1–25. https://doi.org/10.1016/j.ajhg.2025.07.020
Lyrics:
Verse 1
In a dish-lit dawn, the blueprints bend and slide
Rooms in the genome open, walls don’t align
Loops start talking to strangers across the line
And the map we trusted redraws overnight
Pre-Chorus
Progenitors slow down, stuck in the waiting room
G1 holds the door like a quiet, heavy tune
Small worlds don’t grow the way they’re meant to bloom
But the signal keeps climbing through the gloom
Chorus
Miswired in 3D, but I can still feel the beat
Chromatin crossing lines, making new streets
Fast-grown branches, sparks at the synapse meet
When the K+ won’t hold, the fire won’t sleep
Miswired in 3D—hear my heartbeat
Verse 2
Ventricles widen like a hollow, bright frame
Fewer hands dividing, but the questions stay the same
Every cell type carries part of the changed name
A chorus of transcripts shifting in the rain
Bridge
Turn down the noise, find the channel that’s gone
Give the current back its calm, make the brakes hold on
If the cycle can restart, if the timing comes strong
Maybe miswiring learns a softer song
Final Chorus
Miswired in 3D, but I can still feel the beat
Fold the truth from the loops to the firing sheet
From organoid shadows to a clear retreat
Name the pathway, trace the heat
Miswired in 3D—now we’re closer to relief
