Show Notes
This release contains only the music track from Base by Base Episode 383.
Song title: Trans Signals in the Bloodlight
Original Base by Base episode: 383: Genetics of the Circulating Proteome: pQTLs, Pathways, and Disease Links
Article metadata:
Article title: Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
Journal: Cell
DOI: 10.1016/j.cell.2026.03.049
Reference: Koprulu M., Smith-Byrne K., Ferolito B.R., et al., 2026. Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome. Cell 189, 3339–3357. https://doi.org/10.1016/j.cell.2026.03.049
Lyrics:
Verse 1
Late-night screens and a sea of names,
Thirty-eight crowds, one pulse in frames,
Proteins drifting like paper kites,
Genes pull strings from distant sites.
Pre-Chorus
Not just next door, not the closest key,
The loudest levers move silently,
Across the map, through hidden lanes,
A distant switch rewrites the veins.
Chorus
It’s trans, trans—across the line,
Distant hands draw the design,
Sugar-coats and secret roads,
Turning whispers into codes,
Read the blood like city light—
Find the driver, not the hype.
Verse 2
Glyco gears in the dark run true,
N-linked loops in a midnight queue,
Liver sparks, immune drums,
Cell-type choirs where the signal comes.
Bridge
Biomarkers shine, but they can mislead,
Cis says “cause,” while the charts just “read,”
Triangulate—don’t fall in love,
Follow the effector from glove to glove.
Final Chorus
It’s trans, trans—across the line,
Distant hands draw the design,
From protein storms to disease routes,
We tag the targets, we test the doubts,
New paths open, sharp and bright—
Find the driver, not the hype.
