Show Notes
This release contains only the music track from Base by Base Episode 36.
Song title: Two Copies, One Signal
Original Base by Base episode: 36: Bi-allelic POPDC2 variants and a recessive cardiac syndrome
Article metadata:
Article title: Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2025.04.016
Reference: Nicastro M, Vermeer AMC, Postema PG, et al. Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy. The American Journal of Human Genetics. 2025;112:1–18. doi:10.1016/j.ajhg.2025.04.016
Lyrics:
Verse 1
Late-night screens in a quiet lab glow
A rhythm stutters under skin and bone
Two tiny letters in a hidden code
Turn one steady heartbeat into stone
Pre-Chorus
When the message can’t hold on to the spark
When the gate won’t open in the dark
You can hear the silence leave its mark
Chorus
Two copies, one signal, breaking the line
A whisper of cAMP can’t find its time
And the current that should carry me through
Fades out when POPDC2 can’t pull TREK-1 to
Two copies, one signal—tell me what to do
Verse 2
Family traces in an ECG trace
Pauses and blocks where the pulse should run
A wall of muscle growing out of place
Like a storm building up around the sun
Bridge
But one good copy doesn’t write the fall
In crowded datasets, there’s no loud call
So we name the pattern, frame the clue
Put the right gene on the test, see it through
Final Chorus
Two copies, one signal, breaking the line
A whisper of cAMP can’t find its time
Now the map gets clearer in the blue-white light
We can catch the quiet chaos in the night
Two copies, one signal—turn the fear into sight
