Silence the Spark

This release contains only the music track from Base by Base Episode 448.

Song title: Silence the Spark
Original Base by Base episode: 448: PrP‑lowering ASOs prolong survival in prion‑infected mice

Article metadata:
Article title: Antisense oligonucleotides extend survival of prion‑infected mice
Journal: JCI Insight
DOI: 10.1172/jci.insight.131175
Reference: Raymond GJ, Tran Zhao H, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O’Keefe R, Lubke LDL, Reidenbach AG, Kraus A, Schreiber SL, Mazur C, Cabin DE, Carroll JB, Minikel EV, Kordasiewicz H, Caughey B, Vallabh SM. Antisense oligonucleotides extend survival of prion‑infected mice. JCI Insight. 2019;4(16):e131175. https://doi.org/10.1172/jci.insight.131175.

Lyrics:
Verse 1
Late-night benches, glass and steel,
A quiet hunter you can’t feel,
One wrong fold makes shadows grow,
In fragile circuits moving slow.

Pre-Chorus
But on the screen a pattern clears,
A simple cut through tangled fears,
Turn the message down at the source,
And change the ending, change the course.

Chorus
Silence the spark, slow the storm,
Lower the signal, keep the form,
If the script won’t shout, the fire won’t start,
We buy back time, we guard the heart.
Silence the spark, let dawn arrive.

Verse 2
A measured dose, then wait and see,
Threads of warning in chemistry,
Not by luck, not by disguise—
It’s RNA where the answer lies.

Bridge
Even when the damage is written in the halls,
Even when the night feels heavy on the walls,
You can still pull the volume from the pain,
Slow the misfold, break the chain.

Final Chorus
Silence the spark, slow the storm,
Lower the signal, keep the form,
Less of the maker, less of the mark,
Misfolded mountains fade to dark.
Silence the spark—let life extend,
Hold the line, and bend the end.