Show Notes
This release contains only the music track from Base by Base Episode 406.
Song title: Cold Side of the Gut
Original Base by Base episode: 406: Temperature & Age Shape Gut Susceptibility to HCoV-229E
Article metadata:
Article title: Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2600632123
Reference: Synowiec A., Lie L.K., Szczepański A., et al. Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E. Proc. Natl. Acad. Sci. U.S.A. 2026;123(26):e2600632123. https://doi.org/10.1073/pnas.2600632123
Lyrics:
Verse 1
Neon in the lab, midnight on the clock,
We set that warm line, then we let it drop.
Same cells, same gate, but the world rewinds—
At thirty-two the virus finds time.
Pre-Chorus
Quiet alarms in the innate reply,
Less of the warning, more room to climb.
Screens light up with the rising load—
A colder state and an open road.
Chorus
Temperature tells it when to run,
Cold makes a cradle, heat stops the fun.
In the enterocytes, it stakes its claim,
But at thirty-seven it can’t play the same.
Turn the dial, watch the story cut—
Cold side of the gut, cold side of the gut.
Verse 2
Fetal and young still catch that wave,
Adults switch gears and won’t behave.
Translation slows, metabolism bends,
Stress-path signals draw the ends.
Bridge
One receptor, one lock: ANPEP on the door,
Protease like a razor, it wants a little more.
But camostat cuts the spark mid-flight,
Shut down entry, fade out the bite.
Final Chorus
Temperature tells it when to run,
Cold makes a cradle, heat stops the fun.
In the enterocytes, it stakes its claim,
But grown-up heat won’t feed the flame.
Turn the dial, let the data erupt—
Cold side of the gut, cold side of the gut.
