Show Notes
This release contains only the music track from Base by Base Episode 86.
Song title: More Than One Switch
Original Base by Base episode: 86: Why Pathogenic Variant Impact Varies: Variant Effects, Polygenic Background, and Epistasis
Article metadata:
Article title: Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions
Journal: Nature Communications
DOI: 10.1038/s41467-025-60339-7
Reference: https://doi.org/10.1038/s41467-025-60339-7
Lyrics:
Verse 1
I used to think one letter was the flame
A single glitch that sealed a future’s name
But bodies don’t obey a one-line code
They’re weather maps on an electric road
Pre-Chorus
A quiet score in the fold of a protein night
A thousand small pushes turning left to right
And hidden threads where two truths intertwine
It’s never just one sign
Chorus
It’s more than one switch, more than one spark
A bright-screen prophecy in the dark
Your “yes” and “no” live on a sliding scale
In the weight of the common and the rare
We don’t read fate—we measure how it’s shared
Verse 2
Some “healthy” hearts can carry heavy strain
When background noise keeps shouting through the veins
And some who hold a variant marked severe
Stay steady when the whole crowd pulls them clear
Bridge
So give me the signal, the context, the scene
The subtle interaction in-between
Add up the whispers, the risk, the ties
Until the pattern opens its eyes
Final Chorus
’Cause it’s more than one switch, more than one spark
A bright-screen breakthrough in the dark
From missense weight to polygenic air
To edges where the pathways pair
We don’t judge a name—we learn what gets you there
