Show Notes
This release contains only the music track from Base by Base Episode 110.
Song title: Fault Lines in the Code
Original Base by Base episode: 110: Rare coding variants implicate STAG1 and ZNF136 in schizophrenia
Article metadata:
Article title: Whole-exome sequencing analysis identifies risk genes for schizophrenia
Journal: Nature Communications
DOI: 10.1038/s41467-025-62429-y
Reference: Chick SL et al., Whole-exome sequencing analysis identifies risk genes for schizophrenia. Nature Communications (2025). DOI: 10.1038/s41467-025-62429-y
Lyrics:
Verse 1
Late-night screens, a quiet glow
We comb the letters down to bone
Tiny breaks where shadows grow
In lines of life we call our own
Pre-Chorus
Not just one spark, not one name
It’s patterns hiding in the frame
Pull the thread, feel it pull back
A stitched-up sky with subtle cracks
Chorus
Hear the pulse in the silent room
Chromatin knots and a GABA tune
Rare little switches, heavy like stone
Fault lines in the code we’re shown
But we’re learning where the dark begins
So we can build the light back in
Verse 2
A clipped-off protein, a missing end
A bent-up message, mis-sent, misread
Some signals cross where they shouldn’t land
Some brakes don’t bite inside the head
Bridge
And common waves meet rare extremes
On overlapping seams of genes
Not destiny, not blame, not curse
Just maps that help us do the work
Follow-up fire, models to grow
From what the exomes dared to show
Final Chorus
Hear the pulse in the silent room
Cohesin holding, then coming loose
Transport misfiring, out of tone
Fault lines in the code we’re shown
Now the names rise up like neon signs
Pointing to pathways we can redesign
From stitched-up nights to a clearer view
We find the thread—and we pull it through
