Show Notes
This release contains only the music track from Base by Base Episode 457.
Song title: One Less, One More
Original Base by Base episode: 457: A deletion that raises Alzheimer risk, a duplication that lowers it
Article metadata:
Article title: Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.07.013
Reference: Quenez O, Schramm C, Cassinari K, Nicolas A, Groeneveld J, Huguet G, et al. Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk. The American Journal of Human Genetics. 2026;113(10):1-19. doi:10.1016/j.ajhg.2026.07.013
Lyrics:
Verse 1
Twenty-two thousand read.
Every letter, every gap.
One little stretch of twenty-two
kept showing on the map.
Pre-Chorus
One side heading down.
One side climbing up.
Same short street, same short block —
different measure in the cup.
Chorus
ONE LESS — and the risk goes UP.
ONE MORE — and it settles DOWN.
Same little piece of the same little place
turning it around.
ONE LESS — only in the early years.
ONE MORE — easy in the crowd.
Same little piece, read it twice:
count it, count it out loud.
Verse 2
Not one deletion showed
in nine thousand walking free.
But the doubles kept on turning up
right where you want to be.
Chorus
ONE LESS — and the risk goes UP.
ONE MORE — and it settles DOWN.
Same little piece of the same little place
turning it around.
Bridge
Put the gene back in the cell —
it clears the plaque right up.
That's the piece we can see so far.
Rare is rare enough.
It ain't a shield. It's a lean.
It tilts you. It don't save.
Some who carried two of them
still came the harder way.
Final Chorus
ONE LESS — and the risk goes UP.
ONE MORE — and it settles DOWN.
Not a promise, just a tilt,
but you take it when it's found.
ONE LESS. ONE MORE.
Same little piece, both ways.
Count it once, then count again —
that's the whole thing, right there.
