Show Notes
This release contains only the music track from Base by Base Episode 366.
Song title: Circle in the Static
Original Base by Base episode: 366: BRCA1P1 suppresses antiviral and antitumor immunity
Article metadata:
Article title: Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2528911123
Reference: Han YJ, Zhang J, Shariff M, Wu S, Khramtsova G, Nguyen LC, Peiffer DS, Li N, Lewicka A, Moore M, Piccirilli JA, Olopade OI. Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers. Proc Natl Acad Sci U S A. 2026;123(19):e2528911123. doi:10.1073/pnas.2528911123
Lyrics:
Verse 1
In the lab-light glow, where the cold gels shine,
A ghost of a gene drew a hidden line.
It looped into a circle, quiet and tight,
Holding back the thunder in the middle of the night.
Pre-Chorus
RelA at the doorway, keys in its hand,
But the lock kept turning like shifting sand.
Then we cut the whisper, broke the subtle chain,
And the room filled up with signal like rain.
Chorus
When the circle lets go, the sirens sing,
Interferon fire with a silver sting.
Turn on the warning, let the dark cells know:
You can’t hide forever when the defenses glow.
Verse 2
Tumor shadows talking in a borrowed tone,
Keeping the cytokines low, keeping danger prone.
But when that loop went missing, the story flipped fast,
More cracks in the armor, more weight on the past.
Bridge
Macrophage hands reach in, clear the floor,
T-cells press closer at the tumor door.
Apoptosis rising like a hard-earned dawn,
And the silent advantage is suddenly gone.
Final Chorus
When the circle lets go, the sirens sing,
Interferon fire with a silver sting.
Turn on the warning, let the dark cells know:
We’re built to survive—watch the defenses glow.
