Show Notes
This release contains only the music track from Base by Base Episode 371.
Song title: Open the Switches in the Dark
Original Base by Base episode: 371: Glial epigenomic dysregulation and genetic risk in tauopathies
Article metadata:
Article title: Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states
Journal: Nature Communications
DOI: 10.1038/s41467-026-73007-1
Reference: Han, X., Rosenberg, G.M., Kisling, V.M. et al. Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states. Nat Commun (2026). https://doi.org/10.1038/s41467-026-73007-1
Lyrics:
Verse 1
In the quiet of a brain gone dim,
I watch the shadows under every skin.
Tiny doors in the DNA glow,
Opening paths we didn’t know.
Pre-Chorus
Risk isn’t loud, it hides in the seams,
In folded signals and broken routines.
But when the map starts coming alive,
You can feel the cells decide.
Chorus
Open the switches in the dark,
Let the glia find their spark.
From the static, from the noise,
We turn the locks, we raise the voice.
Carry the load, clear the track—
We’re bringing the rescue pathways back.
Verse 2
Microglia counting what the damage costs,
Astrocytes holding lines that got crossed.
Co-access wires, linked like chains,
Point to the places that carry the strain.
Bridge
Lysosomes running like engines at night,
Phagocytic hands reaching for light.
Sphingolipids, vesicles, threads in time,
SNARE-tight knots in a rhythm and climb.
SOX10 rising when the stress gets loud,
MEF2 calling order out of the crowd.
Final Chorus
Open the switches in the dark,
Let the glia find their spark.
Risk becomes real, then it can bend—
We name the circuit, we can mend.
Carry the load, clear the track—
We’re bringing the rescue pathways back.
