Show Notes
This release contains only the music track from Base by Base Episode 370.
Song title: Methyl to the Membrane
Original Base by Base episode: 370: ICMT and INPP5E enable BRAFV600E tumor growth
Article metadata:
Article title: ICMT supports BRAF
V600E
-driven tumor growth by membrane targeting of the CAAX protein INPP5E
Journal: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.2601795123
Reference: Yang X, Qiao X, Schmidt S, et al. ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E. PNAS. 2026;123(20):e2601795123. doi:10.1073/pnas.2601795123
Lyrics:
Verse 1
Neon in the lab, the numbers won’t lie
A single hot switch, and the shadows multiply
Cells on the run with a fire in their code
But every fast escape leaves a trace on the road
Pre-Chorus
There’s a tiny mark where the story turns
A quiet enzyme and the pressure burns
If the anchor slips, the signal fades
And the invader stalls in the light it made
Chorus
Put the methyl to the membrane, let it hold or break
Cut the tether, watch the crash, feel the pathway shake
When the surface won’t receive what it used to take
The growth can’t find its rhythm, it’s a storm on a lake
Verse 2
CAAX at the end like a tag on a thread
Pulled to the edge where the living is fed
INPP5E rides where the lipids glow
If it can’t dock in, it can’t keep the flow
Bridge
And PI(4,5)P2 rises like a tide
Changing the shoreline where the killers hide
Even when resistance says “I’m here to stay”
A new kind of block can get in the way
Final Chorus
Put the methyl to the membrane, let it hold or break
Cut the tether, watch the crash, feel the pathway shake
When the surface won’t receive what it used to take
The growth can’t find its rhythm—now it’s wide awake
