Show Notes
This release contains only the music track from Base by Base Episode 68.
Song title: One-Beat Duplicate
Original Base by Base episode: 68: Indels Enable One-Step Antiviral Innovation in TRIM5a
Article metadata:
Article title: Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
Journal: Cell Genomics
DOI: 10.1016/j.xgen.2025.100818
Reference: Tenthorey JL, del Banco S, Ramzan I, Klingenberg H, Liu C, Emerman M, Malik HS. Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations. Cell Genomics. 2025;5:100818. doi:10.1016/j.xgen.2025.100818
Lyrics:
Verse 1
Late-night glow on a stainless stage,
A loop that drifts like a restless wave,
We chased one letter, tried every shade,
But the lock stayed cold, the door stayed chained.
Pre-Chorus
Then a tiny echo slipped in the line,
Not a swap—just time, then time,
One extra step in the same old dance,
And the whole skyline changed at once.
Chorus
Add a beat, let it fold—watch the virus lose its hold,
One small duplicate, and the target turns to gold,
From “can’t” to “can,” in a single pulse it shows,
Length and spacing write the code nobody knows.
Verse 2
We mapped the heat where the winners rise,
Missense roads all dead-end signs,
Six-step climb just to match that view,
But one clean indel cut right through.
Bridge
In the disorder, there’s hidden design,
A softer thread that can realign,
Not just survival—new sight, new reach,
A sharper grip with a simple stitch.
Final Chorus
Add a beat, let it fold—watch the virus lose its hold,
One small duplicate, and the target turns to gold,
Wide as the night, it can catch what it chose,
One-beat miracle—new function in the flow.
