Show Notes
This release contains only the music track from Base by Base Episode 69.
Song title: Turn the Key on PLK1
Original Base by Base episode: 69: PLK1 overexpression exposes an IGF2BP2 vulnerability
Article metadata:
Article title: Three independent approaches identify IGF2BP2 as a top SDL target of PLK1
Journal: Cell Genomics
DOI: 10.1016/j.xgen.2025.100876
Reference: Cunningham C.E., Vizeacoumar F.S., Zhang Y., Kyrylenko L., Both S., Maranda V., et al.. Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality. Cell Genomics, 5, 100876. (2025). https://doi.org/10.1016/j.xgen.2025.100876
Lyrics:
Verse 1
Neon lab lights, another midnight run
A thousand wild cells, but the signal’s one
PLK1 burning like a warning flare
Fast-dividing shadows filling up the air
Pre-Chorus
We mapped the noise, we watched it split and grow
But every path kept pointing to one switch we know
If it’s held up, the whole machine can fly
If it slips, those heavy wheels run dry
Chorus
Hallelujah, found the thread in the storm
Pull IGF2BP2, watch the pattern deform
When it can’t hold messages tight, they fall away
And the PLK1-high giants lose their sway
Hallelujah, turn the key, let it break
Make the loudest growth go silent in the wake
Verse 2
Three separate roads, they all arrived the same
Different screens, but they called out one name
Single-cell whispers on a clustered page
Said, “It’s the stabilizer feeding up the rage”
Bridge
Not every answer makes it to the bedside light
But in these living models, you can see the fight
Destabilize the words that keep the engine fed
And watch the swelling curve bend back instead
Final Chorus
Hallelujah, found the thread in the storm
Pull IGF2BP2, watch the pattern deform
Let the transcripts scatter, let the false strength fade
’Til the PLK1-high empire can’t be made
Hallelujah, hold your hope, stay awake
From the screen to the tumor, feel the change we make
