Show Notes
This release contains only the music track from Base by Base Episode 368.
Song title: Cut the Static, Save the Signal
Original Base by Base episode: 368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model
Article metadata:
Article title: PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model
Journal: PNAS
DOI: 10.1073/pnas.2525028123
Reference: Jhaldiyal A., Kumari M., Guttman L. C., et al. PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model. PNAS (2026). DOI: 10.1073/pnas.2525028123
Lyrics:
Verse 1
Bright screen glow in the after-hours
Little shards in the synapse air
A whispered storm that never showers
Leaves a fracture everywhere
Pre-Chorus
When the damage starts to flicker
You can hear the cells go thin
But there’s a switch inside the circuit
Let the quiet fight begin
Chorus
Cut the static, save the signal
Don’t let the memory burn
Turn down PAR, break the spiral
Let the tide reverse and turn
Less made, more cleared—hold the line
We can slow the fall with time
Verse 2
Oligomers knock like broken rhythm
Set off alarms in neural code
But if PARP1 can’t feed the system
The heavy chain won’t overload
Bridge
Lower the blade that makes the fragments
Shift the gears that shape the cut
Raise the cleaner in the current
So the dark can’t pile up
Final Chorus
Cut the static, save the signal
Don’t let the memory burn
Turn down PAR, break the spiral
Let the tide reverse and turn
Less made, more cleared—hold the line
We can draw new maps from time
