Show Notes
This release contains only the music track from Base by Base Episode 369.
Song title: Break the Efflux
Original Base by Base episode: 369: NEK2 drives EBV-positive NHL pathogenesis
Article metadata:
Article title: NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma
Journal: PNAS
DOI: 10.1073/pnas.2535550123
Reference: White MC, Lange PT, Stewart J, Damania B. NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma. Proc Natl Acad Sci U S A. 2026;123:e2535550123. doi:10.1073/pnas.2535550123
Lyrics:
Verse 1
Midnight in the lab, bright screen, steady hand
A quiet enemy hides where the signals land
It teaches the cells how to never let go
Pumping out the cure like a practiced flow
But we traced the switch that keeps it all aglow
Pre-Chorus
Follow the current, it’s pulling the wires
One kinase spark lighting bigger fires
Hold that lever, watch the armor fall
When the gate goes down, the echoes call
Chorus
Break the efflux, cut the line, let it burn clean
Shut the engine down, make the dark unseen
When the pumps stop running, hope gets in
Turn resistance into paper-thin skin
Hit the switch—watch the tide begin
Verse 2
A viral whisper keeps the survival song
Names on the membrane humming all night long
Beta-catenin dreaming, myc in the glow
Pro-survival prayers in a brutal row
Till an iron-lock inhibitor says “No”
Bridge
Oxygen storms and a crimson flare
Inflammation rising through the air
Gasdermin tearing open the seal
A final warning the cells can feel
And the burden drops—more time is real
Final Chorus
Break the efflux, cut the line, let it burn clean
Drop the defenses, make the path unseen
When the pumps stop running, chemo gets in
Turn resistance into paper-thin skin
Hold the switch—let the new day begin
