Show Notes
This release contains only the music track from Base by Base Episode 72.
Song title: Basal Body Blues (POC5)
Original Base by Base episode: 72: POC5 ciliopathy: retinal, endocrine and neuromuscular syndrome
Article metadata:
Article title: Bi-allelic loss-of-function variants in POC5 cause a syndromic retinal, endocrine and neuromuscular ciliopathy
Journal: Genetics in Medicine
DOI: 10.1016/j.gim.2025.101513
Reference: Vulto-van Silfhout AT, Jazet IM, Yzer S, et al. Bi-allelic loss-of-function variants in POC5 cause a syndromic retinal, endocrine and neuromuscular ciliopathy. Genetics in Medicine (2025). doi: https://doi.org/10.1016/j.gim.2025.101513
Lyrics:
Verse 1
Late-night lights on a bench-top glow,
Families tracing what they can’t outgrow,
A missing piece in the body’s frame,
Two quiet breaks with the same last name.
Pre-Chorus
If the message stops, the cell lets go,
Cuts the transcript down, runs NMD low,
And the compass at the center won’t align,
So the edges blur, one thread at a time.
Chorus
Hold on—there’s a reason in the code,
POC5 fades and the signal slows,
From sight to sugar to aching lines,
Small flaws in cilia, big fault lines.
We don’t look away, we follow through,
Name the pattern, make it visible.
Verse 2
Rings in the dark where the vision thins,
Insulin fighting battles it never wins,
Muscle cramps like a wire pulled tight,
Kidneys whisper warnings in the middle of the night.
Bridge
At centrioles, where the map begins,
Centrin shifts, the anchor spins,
Not a total collapse—just off-beat steps,
A modest storm in a system of depth.
Final Chorus
Hold on—there’s a reason in the code,
POC5 fades and the signal slows,
From sight to sugar to aching lines,
Small flaws in cilia, big fault lines.
Test the gene, watch the signs in time,
Many hands, one line—keep them alive.
