Show Notes
This release contains only the music track from Base by Base Episode 71.
Song title: When the Signal Won’t Land
Original Base by Base episode: 71: ELFN1 Deficiency: Mechanisms and Clinical Spectrum
Article metadata:
Article title: ELFN1 Deficiency: the mechanistic basis and phenotypic spectrum of a neurodevelopmental disorder with epilepsy
Journal: Genetics in Medicine
DOI: 10.1016/j.gim.2025.101506
Reference: Dore R, Chang CT, Declève A, Brunori G, Ludlam WG, Huang A, Movahedinia M, Damseh NS, Anwar I, Vahidi Mehrjardi MY, Ny A, Khorrami M, Kheirollahi M, Frederiksen H, Eghbal F, Mirjalili MR, Dehghani M, Karimiani EG, Oreshkov S, Alves C, Striano P, Suri M, Martinez-Agosto J, Ansar M, Zahid M, Akram S, Ansar M, Nelson SF, Undiagnosed Diseases Network, Antonarakis SE, Houlden H, Copmans D, Martemyanov KA, Maroofian R. ELFN1 Deficiency: the mechanistic basis and phenotypic spectrum of a neurodevelopmental disorder with epilepsy. Genetics in Medicine. 2025. doi: https://doi.org/10.1016/j.gim.2025.101506
Lyrics:
Verse 1
Late-night sparks in a wired-up mind,
Messages knocking but they can’t align.
A door in the synapse won’t open wide,
So the current stutters, nowhere to hide.
Pre-Chorus
If the anchor can’t reach the outer skin,
The whispers fade where they should begin.
No handshake held, no rhythm stays,
Just runaway flashes in crowded waves.
Chorus
When the signal won’t land, the whole world shakes,
Lightning in the quiet, and the body breaks.
But we trace the fault line, name what’s gone wrong,
Find the lost connection, bring it back strong.
Verse 2
Tiny changes in the folded frame,
Shift one piece and it won’t play the same.
A binding promise that slips away,
Group-three echoes that won’t obey.
Bridge
In glass-lit rooms and flickering screens,
We follow the pathway no one sees.
From surface to synapse, from code to sound,
Turn loss into map—set hope down.
Final Chorus
When the signal won’t land, the whole world shakes,
But we’re learning the pattern the seizure takes.
We pull the thread till the truth runs clear,
Target the synapse—let the future steer.
