Show Notes
This release contains only the music track from Base by Base Episode 451.
Song title: Lower the Signal
Original Base by Base episode: 451: Prion protein lowering is disease-modifying across stages and strains
Article metadata:
Article title: Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
Journal: Nucleic Acids Research
DOI: 10.1093/nar/gkaa616
Reference: Minikel EV, Zhao HT, Le J, O’Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-ura K, Beck M, O’Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints. Nucleic Acids Research. 2020;48(19):10615–10631. doi:10.1093/nar/gkaa616
Lyrics:
Verse 1
White coats in the midnight haze,
Quiet fear in electric days,
A tiny thread in a twisted code,
If we cut it down, can we change the road?
Pre-Chorus
Needles of language, under the skin,
Turn down the message, don’t let it win,
When the damage starts to speak in light,
We listen close, then we rewrite.
Chorus
Lower the signal, slow the fire,
Pull that shadow off the wire,
Even a little can bend the line,
Hold on—this time, time is on our side.
Verse 2
Different shapes wear the same cold grin,
Five hard rhythms, they all rush in,
But the quiet knock on the RNA door
Makes the warning fade like it did before.
Bridge
When the blood says “hurt” and the glial lights rise,
We don’t look away—we steady our eyes,
After the tipping point, we still can steer,
Some hearts come back from the edge of fear.
Final Chorus
Lower the signal, slow the fire,
Pull that shadow off the wire,
Across the stages, the proof still shines,
Hold on—this time, time is on our side.
