Show Notes
This release contains only the music track from Base by Base Episode 34.
Song title: Sink the Signal
Original Base by Base episode: 34: Pegtibatinase in Classical Homocystinuria (COMPOSE)
Article metadata:
Article title: Safety and efficacy of pegtibatinase enzyme replacement therapy in adults with classical homocystinuria in the COMPOSE phase 1/2 randomized trial
Journal: Genetics in Medicine (2025) 27, 101456
DOI: 10.1016/j.gim.2025.101456
Reference: Ficicioglu C, Thomas JA, Ganesh J, Kudrow D, Lah M, Smith WE, Guner J, McDermott S, Vaidya SA, Wilkening L, Levy HL. Safety and efficacy of pegtibatinase enzyme replacement therapy in adults with classical homocystinuria in the COMPOSE phase 1/2 randomized trial. Genetics in Medicine. 2025;27:101456. doi:10.1016/j.gim.2025.101456
Lyrics:
Verse 1
White coat, late night, numbers on a screen
A storm in the bloodstream, quiet and unseen
Tried to hold the line with rules that feel so tight
But the needle found a pathway back to light
Pre-Chorus
A small shot, a new start, under the skin it goes
Catching what was rising, where the burden flows
Turning down the danger, steady as a drum
Balance in the cycle, here it comes
Chorus
Sink the signal, let it fall
Bring the pressure down in the bloodstream’s call
From too high to under control
Find the rhythm, find the role
Sink the signal, make it right
Give the body back its own green light
Verse 2
Dose by dose, it answers, stronger every time
Fifty-seven, sixty-seven—watch that curve decline
No crash, no sirens, holding steady through the weeks
A pathway re-aligning, in the language that it speaks
Bridge
Antibodies whisper, then they fade like rain
Still the arc is moving, still we break the chain
Metabolites returning to a steadier glow
Not the end of the story—just the proof we can go
Final Chorus
Sink the signal, let it fall
Keep the danger low, hear the future call
From the edge to a calmer goal
Let the balance take control
Sink the signal, hold on tight
Step by step into a wider life
