Show Notes
This release contains only the music track from Base by Base Episode 33.
Song title: Proof in the Peptides
Original Base by Base episode: 33: Targeting mis-splicing-derived neoantigens in splicing factor mutant leukemias
Article metadata:
Article title: Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias
Journal: Cell
DOI: 10.1016/j.cell.2025.03.047
Reference: Kim WJ, Crosse EI, De Neef E, et al. Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias. Cell. 2025;188:1–19. doi:10.1016/j.cell.2025.03.047
Lyrics:
Verse 1
In the midnight lab where the errors hide,
A single letter slips, and the script rewrites.
Fragments of a message never meant to survive,
Still make a new shape in the cell’s cold light.
Pre-Chorus
Cut wrong, stitched strange, but it leaves a trace,
A secret tag on the surface plane.
If the code can lie, it can give us a face—
Something to name, something to aim.
Chorus
Proof in the peptides, up on HLA,
A new little flag where the shadows lay.
We don’t need perfect, we just need true—
A shared bright target to pull us through.
Proof in the peptides, hear the signal sing,
Find the right receptor, let the counterswing.
From mis-spliced lines to a fighting view:
We can teach T cells what to do.
Verse 2
Screens glow blue with the splice-site bends,
Heatmap pulses like a warning sign.
Predict, then test till the doubt all ends,
Mass-spec whispers, “Yes—this binds.”
Bridge
And even when patient sparks run dim,
When pathways falter and fire won’t rise,
We can lend a tuned-in engine to them—
A borrowed key for locked inside.
In living models the burden falls,
Not by luck, but by design.
Final Chorus
Proof in the peptides, up on HLA,
Common missteps turned a doorway way.
We don’t need perfect, we just need true—
A public target to carry us through.
Proof in the peptides, let the last note land:
Clone that answer, put it in the hand.
From wrong-cut words to a clearer view—
We can teach T cells what to do.
