Show Notes
This release contains only the music track from Base by Base Episode 365.
Song title: Pocket Full of Proof
Original Base by Base episode: 365: MEN1 mutations and menin inhibitor resistance
Article metadata:
Article title: CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
Journal: Nature Communications
DOI: 10.1038/s41467-026-72685-1
Reference: Bourgeois, W., Rice, H.E., Wenge, D.V. et al. CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials. Nat Commun (2026). https://doi.org/10.1038/s41467-026-72685-1
Lyrics:
Verse 1
Bright screens in the midnight lab,
Tiny letters change the map.
One swap in the lock’s pure shape,
And the key don’t fit the latch.
Pre-Chorus
We watched the numbers rise and slide,
Same drug, different ride.
In the pocket where partners meet,
A single bump can shift the beat.
Chorus
In the binding pocket, sparks and stone,
Some changes stand, some changes don’t.
Push comes to pressure, cells hold the line,
Resistance learns in real time.
But now we see it, clean and close—
A pocket full of proof, and a better dose.
Verse 2
We edited base by base,
Let the variants show their face.
Some went broad, some played it sly,
One blocker fails, another might.
Bridge
Crystal-clear in black and white,
Steric clashes in the light.
When contact breaks, affinity falls,
And the living system answers the call.
Final Chorus
In the binding pocket, sparks and stone,
Some changes stand, some changes don’t.
Under drug-lit nights the pattern shines,
Resistance writes its own designs.
But now we name it, we choose our road—
A pocket full of proof, and a next-gen hope.
