Show Notes
This release contains only the music track from Base by Base Episode 78.
Song title: Endosome Lantern
Original Base by Base episode: 78: Unloading Lipids: TTYH2 Meets APOE
Article metadata:
Article title: Interactions between TTYH2 and APOE facilitate endosomal lipid transfer
Journal: Nature
DOI: 10.1038/s41586-025-09200-x
Reference: Sukalskaia A., Karner A., Pugnetti A., Weber F., Plochberger B. & Dutzler R. Interactions between TTYH2 and APOE facilitate endosomal lipid transfer. Nature. doi:10.1038/s41586-025-09200-x (2025).
Lyrics:
Verse 1
In the dim of a drifting vesicle, I watch the cargo slow
A halo of lipids circling, looking for somewhere to go
A messenger at the surface, holding steady in the glow
And a hidden door in the membrane, where the quiet currents flow
Pre-Chorus
No scramble, no chaos—just a guided slide
A hand at the threshold where the bilayers hide
Tip to the lumen, lining up the ride
Like truth in the dark when the pictures coincide
Chorus
Let it move, let it move—through the hollow, through the seam
From the lipoprotein’s edge to the membrane like a stream
TTYH2 and APOE, turning contact into theme
A passage for the fat of life, a lantern in the dream
Verse 2
Pull-down whispers, fractions tell where the partners meet
Bright confocal overlaps in the endosome’s heat
Force curves in a single molecule, a measured little beat
And frozen frames of structure, where the pathway looks complete
Bridge
There’s a cavity, hydrophobic, opening wide to the blue
A continuous road for lipids, from the leaflet slipping through
Not every detail settled, but the signal’s breaking through
If brains trade fuel in silence, this may be one way they do
Final Chorus
Let it move, let it move—through the hollow, through the seam
From the lipoprotein’s edge to the membrane like a stream
TTYH2 and APOE, turning contact into theme
A passage for the fat of life, a lantern in the dream
